Bin1 Polyclonal Antibody for Rat(Rattus norvegicus) | EIAab.comBin1 Polyclonal Antibody for Rat(Rattus norvegicus)

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Bin1 (Gene name),

Myc box-dependent-interacting protein 1 (Protein name ), BIN1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Bin1(Amph2;Amphl);

Protein name:

Myc box-dependent-interacting protein 1;

Alternative:

Amphiphysin-like protein;Amphiphysin II;Bridging integrator 1;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Heterodimer with AMPH. Binds SH3GLB1 (By similarity). Interacts (via SH3 domain) with SYNJ1. Interacts (via SH3 domain) with DNM1. Interacts with CLTC. Interacts with AP2A2. Interacts with AP2B1. Interacts with MYC (via N-terminal transactivation domain); the interaction requires the integrity of the conserved MYC box regions 1 and 2. Interacts with BIN2.

Function:

May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.

Subcellular Location:

Cytoplasm Nucleus

Protein Attributes:

Sequence length:

588

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

588:

EEQDEGWLMG | VKESDWNQHK | ELEKCRGVFP | ENFTERVQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

10116.ENSRNOP00000017573

KEGG:

rno:117028

String:

O08839

Pfam:

PF03114

UniGene:

Rn.17098

Uniprot:

O08839

FOR

ELISA Kit for Rat Myc box-dependent-interacting protein 1

Cat.:

E8983m

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96T

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ELISA Kit for Rat Myc box-dependent-interacting protein 1

Cat.:

E8983r

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MSDS:

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Packing:

96T

ELISA Kit for Rat Myc box-dependent-interacting protein 1

Cat.:

E8983h

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96T

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CLIA Kit for Rat Myc box-dependent-interacting protein 1

Cat.:

U8983h

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96T

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CLIA Kit for Rat Myc box-dependent-interacting protein 1

Cat.:

U8983m

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MSDS:

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Packing:

96T

CLIA Kit for Rat Myc box-dependent-interacting protein 1

Cat.:

U8983r

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MSDS:

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Packing:

96T

Polyclonal Antibody for Rat Myc box-dependent-interacting protein 1

Cat.:

P8983Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Myc box-dependent-interacting protein 1

Cat.:

P8983Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Myc box-dependent-interacting protein 1

Monoclonal Antibody for Rat Myc box-dependent-interacting protein 1

Protein for Rat Myc box-dependent-interacting protein 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Amphiphysin heterodimers: potential role in clathrin-mediated endocytosis."
Wigge P. , Koehler K. , Vallis Y. , Doyle C. , Owen D. , Hunt S.P. , McMahon H.T.
Mol. Biol. Cell8:2003-2015(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBUNIT;ALTERNATIVE SPLICING
strain: Sprague-Dawley.
tissue: Brain cortex.
tissue: Kidney.
2.

"Clathrin interacts specifically with amphiphysin and is displaced by dynamin."
McMahon H.T. , Wigge P. , Smith C.
FEBS Lett.413:319-322(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM AMPH2-1)
strain: Sprague-Dawley.
tissue: Brain cortex.
3.

Lubec G. , Chen W.-Q. , Kang S.U. , Lubec S.
Submitted (2007-09) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 155-164; 190-202; 510-537 AND 577-586;IDENTIFICATION BY MASS SPECTROMETRY
strain: Sprague-Dawley.
tissue: Brain.
tissue: Hippocampus.
4.

"A structural explanation for the binding of multiple ligands by the alpha-adaptin appendage domain."
Owen D.J. , Vallis Y. , Noble M.E.M. , Hunter J.B. , Dafforn T.R. , Evans P.R. , McMahon H.T.
Cell97:805-815(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AP2A2
5.

"Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly."
Traub L.M. , Downs M.A. , Westrich J.L. , Fremont D.H.
Proc. Natl. Acad. Sci. U.S.A.96:8907-8912(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AP2A2
6.

"Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly."
Edeling M.A. , Mishra S.K. , Keyel P.A. , Steinhauser A.L. , Collins B.M. , Roth R. , Heuser J.E. , Owen D.J. , Traub L.M.
Dev. Cell10:329-342(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AP2B1
7.

"Crystal structure of the amphiphysin-2 SH3 domain and its role in the prevention of dynamin ring formation."
Owen D.J. , Wigge P. , Vallis Y. , Moore J.D.A. , Evans P.R. , McMahon H.T.
EMBO J.17:5273-5285(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 506-588;FUNCTION;INTERACTION WITH DNM1

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